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During this period, the powerful nations of the Iroquois Confederacy, based in New York, had maintained control of much of the Ohio Valley as hunting grounds by right of conquest after defeating other tribes.

By the terms of the 1768 Treaty of Fort Stanwix, the Penns were allowed to purchase the modern region from the Iroquois.

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By 1815, Pittsburgh was producing significant quantities of iron, brass, tin, and glass.

On March 18, 1816, the 46-year-old local government became a city.

A 1769 survey referenced the future city as the "Manor of Pittsburgh".

Both the Colony of Virginia and the Province of Pennsylvania claimed the region under their colonial charters until 1780, when they agreed under a federal initiative to extend the Mason–Dixon line westward, placing Pittsburgh in Pennsylvania.

It was served by numerous river steamboats, that increased trading traffic on the rivers.

In the 1830s, many Welsh people from the Merthyr steelworks immigrated to the city following the aftermath of the Merthyr Rising.The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the Pittsburgh area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. Michael Bezallion was the first to describe the forks of the Ohio in a 1717 manuscript, and later that year European fur traders established area posts and settlements.During 1753–54, the British hastily built Fort Prince George before a larger French force drove them off.The following year, the Pittsburgh Post-Gazette was started, and in 1787, the Pittsburgh Academy was chartered.Unrest during the Whiskey Rebellion of 1794 resulted in federal troops being sent to the area.On March 8, 1771 Bedford County, Pennsylvania was created to govern the frontier.

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