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Their meaning comes from comparison to reference ranges.

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If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves.

This is usually the result of an existing condition (also called secondary or reactive thrombocytosis) such as: Rarely, thrombocytosis is caused by a bone marrow disorder.

An example is thrombocythemia, also called primary or essential thrombocythemia, a rare myeloproliferative disorder in which the bone marrow produces an extremely high number of platelets.

At the same time, activated platelets support the coagulation cascade, a series of steps that involves the sequential activation of proteins called clotting factors.

This secondary hemostasis process results in the formation of strands of fibrin that weave through the loose platelet plug, form a fibrin net, and compress to form a stable clot that remains in place until the injury has healed.

This disorder is often associated with a mutation in the gene called JAK2.

A test for this mutation should be performed if a health practitioner suspects that an individual has the disorder.

If there are insufficient platelets, or if platelets are not functioning normally, a stable clot may not form and a person may be at an increased risk of excessive bleeding.

Platelets survive in the circulation about 8 to 10 days, and the bone marrow must continually produce new platelets to replace those that degrade, are used up, and/or are lost through bleeding.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests.

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