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-binding, of agonist activity on vascular smooth muscle, of inhibition of 5-HT uptake into platelets, and of 5-HT antagonism on gastrointestinal smooth muscle.
The absence of all these secondary activities is pharmacologically characteristic for ketanserin when compared to known serotonin-antagonists. Quote: High energy phosphate levels are depressed following global ischemia and require several days to completely recover.
Thirteen of the 16 dogs (81%) had normal or only mildly abnormal myocardial function.
This list is in chronological order, from 1965 to the current date, with the most recent additions added at the bottom of this page. Patent ductus arteriosus in dogs of poodle ancestry and fibrous subaortic stenosis in Newfoundlands were shown provisionally to be transmitted in a manner consistent with autosomal dominant inheritance. In animals in which blood pressure was not restored, plasma renin activity and plasma aldosterone remained elevated throughout the period of constriction. Pressure was measured with a miniature pressure transducer mounted within the balloon.
Hyper-linked titles are linked to the actual articles which are available on-line. The significance of these findings is considered in relation to present and future understanding of the etiology and pathogenesis of congenital heart disease." . Single injections of converting enzyme inhibitor reduced blood pressure when plasma renin activity was elevated. Wide variations in loading conditions were achieved by changing the volume of air above the volumetric chamber.
Serotonin S2-receptors of the rat frontal cortex were labeled by low concentrations of ketanserin (Ki = 0.39 n M), and affinity of drugs for S2-receptors highly correlated with their activity against serotonin-induced contractions of blood vessel preparations (e.g., of the rat caudal artery, A2-value of ketanserin: 0.83 n M) and serotonin-induced platelet aggregation.
In these experiments, ketanserin was devoid of serotonin!
Differences between values obtained on different days were evaluated by analysis of variance. Quote: "The quinazolinedione derivative ketanserin was studied in many known and newly introduced tests to obtain its detailed pharmacological profile.
Satisfactory qualitative echocardiograms were repeatedly obtained by using consistent sites of transducer placement and by identifying internal cardiac structures. Ketanserin was a potent, orally very effective antagonist of endogenous serotonin (5-HT): 0.15 mg/kg (ED50 s.c.
On the basis of this profile of pure and selective serotonin S2-antagonism, ketanserin was studied in experimental hypertension and in many spontaneous and induced circulatory dysfunctions. Quote: "The relationship of myocardial ATP levels and postischemic dysfunction remains controversial. Short-term methods to enhance ATP recovery have included infusion of ATP precursors, inhibition of enzymes that catabolize AMP, and membrane transport stabilization.
A prolonged antihypertensive effect can be obtained with ketanserin in the absence of distinct compensatory mechanisms. In an intact animal model of global ischemia (Isc) and recovery, we have found ribose (R) or adenine (A) and R accelerated the return of ATP levels (84% and 80% recovery by 24 hrs). Several precursors have been used to augment adenine nucleotide synthesis including adenosine, inosine, adenine, and ribose.
Vascular dysfunction can start at low, sensitizing concentrations of serotonin and be almost completely corrected by ketanserin, despite the involvement of other mediators. The purpose of this study was to determine the effects of enhancing ATP recovery on postlsc function. Mahoney, Jr., Kevin Tveter, Stanley Einzig, John E. Because of the short-term nature of previous experiments, recovery had been incomplete and the effects in the intact animal unknown.
Ketanserin is a very effective antagonist of the mixture of vasoactive substances released by aggregating platelets. Following 20 min of Isc on cardiopulmonary bypass, dogs received either R (80m M) (n=S), A (20m M) and R (80m M)(n=5) or saline (NS)(n=6) for 24 hrs. The purpose of this study was to determine the effects of ribose infusion in a long-term model of global ischemia and attempt to identify the precursor which limits myocardial ATP regeneration in the intact animal.
Preliminary genetic studies confirmed the specific hereditary transmission of valvular pulmonic stenosis in beagles, persistent right aortic arch in German shepherds, and conal septal defects (including ventricular septal defects and tetralogy of Fallot) in keeshonden. The initial response to constriction was a reduction in blood pressure, a rise in plasma renin activity, plasma aldosterone, and water intake, and nearly complete sodium retention. Quote: The instantaneous isovolumic and ejecting pressure-volume relationship of the right ventricle was studied in 11 cross-circulated, isolated canine hearts to characterize the right ventricular contractile state.Tags: Adult Dating, affair dating, sex dating