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Complete blood count (CBC) and blood cell exam (peripheral blood smear): The complete blood count (CBC) measures the numbers of red blood cells, white blood cells, and platelets.

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After cleaning the skin over the hip, the doctor numbs the skin and the surface of the bone by injecting a local anesthetic, which may cause a brief stinging or burning sensation.

A thin, hollow needle is then inserted into the bone and a syringe is used to suck out a small amount of liquid bone marrow.

In patients already known to have ALL, these tests can help detect liver or kidney problems caused by spreading leukemia cells or the side effects of certain chemotherapy drugs.

These tests also help determine if treatment is needed to correct low or high blood levels of certain minerals.

If you have signs and symptoms that suggest you might have leukemia, the doctor will want to get a thorough medical history, including how long you have had symptoms and if you have any history of exposure to risk factors.

During the physical exam, the doctor will probably focus on any enlarged lymph nodes, areas of bleeding or bruising, or possible signs of infection.Changes in the numbers and the appearance of the cells often help diagnose leukemia.Most patients with ALL have too many immature white cells in their blood, and not enough red blood cells or platelets.This doctor may run one or more of the tests described below.If your doctor thinks you have leukemia, he or she will need to check samples of cells from your blood and bone marrow to be sure of the diagnosis.The eyes, mouth, and skin will be looked at carefully, and a thorough nervous system exam may be done.

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